S
Stuart Wilson
Guest
"The very act of a fish feeding causes tissue damage – hence detection by endorphins and then simultaneous pain suppression by oparins and repair goes ahead. Much of a fish’s metabolism must be devoted to day-by-day tissue repair and regeneration."
What sort of nonsense is this? A bit like a pharmacologist standing up and explaining to the angling commuinity how fish eveolved from crustaceans!
I am in now way an expert on pain detection but.....
Endorphins do not mediate pain neurotransmission. Why don't you try doing a Google search on "purinoceptor, neurottransmission and pain" and "substance P, neurotransmission and pain". You may learn something.
Oparins - well what the hell are oparins. I've lectured in Pharmacology for years (although not CNS pharmacology) and done searches on Google and Pubmed and can't find a single refence to Oparins / pain perception.
Endorphins are involved in the *perception* of pain, and are found in the brain (although are also present in the gut, which is why morphine / heroine makes you constipated). Endorphins (or enkaphalins) have pain killing effects and surpress pain sensation by the brain. Opiate drugs (heroine, morphine) mimic this effect. These receptors are also involved in all pleasant sensations, which is why opiate drugs are so addictive.
The key to this whole argument is understanding the diffeernce between detecting tissue damage and being able to modify behaviour in a way that avoid sit. This involves nociception and almost all multicellular animals (even sea anenomies and jellyfish) can do this to some extent. Perceiving 'pain' as we understand it is very different event which is dependent upon higher brain function. Do a Google search for Pat Wall - (many orbituaries as he died recently) he is responsible for our current view of pain sensation and our understanding or the way in whch analgesics work. True analgesics prevent the sensation of pain as opposed to local aneasthetics which prevent pain by blocking nociception (the perception of tissue damage).
The arguments set out here will not convince anyone of anything!
What sort of nonsense is this? A bit like a pharmacologist standing up and explaining to the angling commuinity how fish eveolved from crustaceans!
I am in now way an expert on pain detection but.....
Endorphins do not mediate pain neurotransmission. Why don't you try doing a Google search on "purinoceptor, neurottransmission and pain" and "substance P, neurotransmission and pain". You may learn something.
Oparins - well what the hell are oparins. I've lectured in Pharmacology for years (although not CNS pharmacology) and done searches on Google and Pubmed and can't find a single refence to Oparins / pain perception.
Endorphins are involved in the *perception* of pain, and are found in the brain (although are also present in the gut, which is why morphine / heroine makes you constipated). Endorphins (or enkaphalins) have pain killing effects and surpress pain sensation by the brain. Opiate drugs (heroine, morphine) mimic this effect. These receptors are also involved in all pleasant sensations, which is why opiate drugs are so addictive.
The key to this whole argument is understanding the diffeernce between detecting tissue damage and being able to modify behaviour in a way that avoid sit. This involves nociception and almost all multicellular animals (even sea anenomies and jellyfish) can do this to some extent. Perceiving 'pain' as we understand it is very different event which is dependent upon higher brain function. Do a Google search for Pat Wall - (many orbituaries as he died recently) he is responsible for our current view of pain sensation and our understanding or the way in whch analgesics work. True analgesics prevent the sensation of pain as opposed to local aneasthetics which prevent pain by blocking nociception (the perception of tissue damage).
The arguments set out here will not convince anyone of anything!